Professor of Histology and Embryology
Professor of the Department of Histology and Embryology in Ankara University School of Medicine.
Scientific interests include, oocyte and sperm physiology, and embryo development and stem cells.
Currently, my primary research area is oocyte physiology and embryo development.
Please see below.
Stem cells are promising source to treat many diseases. Among them, we focused on human umbilical cord stromal cells and recently, we are running a clinical trial related to cardiovascular disease.
I served as a director and primary embryologist in an IVF lab more than 6 years, then I decided to move my experiences into scientific area for research purpose.
Please visit "My Lectures" page to get my slides.
Slaytlarım için lütfen "Derslerim" sayfasını ziyaret edin.
Oocyte (egg) is a unique cell as it is at the last step of cell differentiation. On the other hand, after fertilization it loses differentiated character and become a totipotent stem cell. Therefore, I think that it is a good model to understand this transaction. Moreover, mitochondria emerge as unique energy source for the oocytes not only with ATP production but also with the role in the oxidative stress and apoptosis.
As a team, we are currently focusing on oxidative stress and organelle interactions in oocyte and their role in oocyte aging and embryo development.
Celikkan FT, Mungan C, Sucu M, Ulus AT, Cinar O, Ili EG, Can A. Optimizing the transport and storage conditions of current Good Manufacturing Practice -grade human umbilical cord mesenchymal stromal cells for transplantation (HUC-HEART Trial). Cytotherapy. 2019 Jan;21(1):64-75. doi: 10.1016/j.jcyt.2018.10.010. Epub 2018 Nov 16.
Can A, Celikkan FT, Cinar O. Umbilical cord mesenchymal stromal cell transplantations: A systemic analysis of clinical trials. Cytotherapy. 2017 Dec;19(12):1351-1382. doi: 10.1016/j.jcyt.2017.08.004. Epub 2017 Sep 28.
Aras D, Cakar Z, Ozkavukcu S, Can A, Cinar O. In Vivo acrylamide exposure may cause severe toxicity to mouse oocytes through its metabolite glycidamide. PLoS One. 2017 Feb 9;12(2):e0172026. doi: 10.1371/journal.pone.0172026.
Cakar Z, Cetinkaya B, Aras D, Koca B, Ozkavukcu S, Kaplanoglu İ, Can A, Cinar O. Does combining magnetic-activated cell sorting with density gradient or swim-up improve sperm selection? J Assist Reprod Genet. 2016 Aug;33(8):1059-65.
Terzioglu F, Turk R, Yucel C, Dilbaz S, Cinar O, Karahalil B. The effect of anxiety and depression scores of couples who underwent assisted reproductive techniques on the pregnancy outcomes. Afr Health Sci. 2016 Jun;16(2):441-50.
Aras D, Cinar O, Cakar Z, Ozkavukcu S, Can A., Can dicoumarol be used as a gonad-safe anticancer agent: an in vitro and in vivo experimental study. Mol Hum Reprod. 2016 Jan 22(1): 57-67.
Can A, Ulus AT, Cinar O, Topal Celikkan F, Simsek E, Akyol M, Canpolat U, Erturk M, Kara F, Ilhan O. Human Umbilical Cord Mesenchymal Stromal Cell Transplantation in Myocardial Ischemia (HUC-HEART Trial). A Study Protocol of a Phase 1/2, Controlled and Randomized Trial in Combination with Coronary Artery Bypass Grafting. Stem Cell Rev. 2015 Jun 28.
Cinar O, Semiz O, Can A., Carbofuran Alters Centrosome and Spindle Organization, and Delays Cell Division in Oocytes and Mitotic Cells. Toxicol Sci. 2015 Apr;144(2):298-306. doi: 10.1093/toxsci/kfu317. Epub 2015 Jan 5.
Kahyaoglu I, Demir B, Turkkanı A, Cınar O, Dilbaz S, Dilbaz B, Mollamahmutoglu L., Total fertilization failure: is it the end of the story? J Assist Reprod Genet. 2014 Sep;31(9):1155-60.
Cinar O, Dilbaz S, Terzioglu F, Karahalil B, Yücel C, Turk R, Taskin L, Kose SK. Does cigarette smoking really have detrimental effects on outcomes of IVF? Eur J Obstet Gynecol Reprod Biol. 2014 Mar;174:106-10.
Guvendag Guven ES, Dilbaz S, Duraker R, Mentese A, Cinar O, Ozdegirmenci O., The effect of cabergoline on folicular microenviroment profile in patients with high risk of OHSS., Gynecol Endocrinol. 2013 Aug;29(8):749-53.
Saglam A, Ozgur C, Derwig I, Unlu BS, Gode F, Mungan T., The role of apoptosis in preterm premature rupture of the human fetal membranes., Arch Gynecol Obstet. 2013 Mar 5.
Demir B, Dilbaz S, Cinar O, Ozdegirmenci O, Dede S, Dundar B, Goktolga U. Estradiol supplementation in intracytoplasmic sperm injection cycles with thin endometrium. Gynecol Endocrinol. 2013 Jan;29(1):42-5.
Cinar O, Demir B, Dilbaz S, Saltek S, Aydin S, Goktolga U. Does empty zona pellucida indicate poor ovarian response on intra cytoplasmic sperm injection cycles? Gynecol Endocrinol. 2012 May;28(5):341-4. Epub 2011 Dec 1
Cinar O, Kara F, Can A. Potential role of decidual apoptosis in the pathogenesis of miscarriages. Gynecol Endocrinol. 2012 May;28(5):382-5. Epub 2011 Nov 21.
Demir B, Dilbaz B, Cinar O, Karadag B, Tasci Y, Kocak M, Dilbaz S, Goktolga U. Factors affecting pregnancy outcome of intrauterine insemination cycles in couples with favourable female characteristics. J Obstet Gynaecol. 2011 Jul;31(5):420-3.
Dilbaz S, Demir B, Cinar O, Dede S, Aydin S, Beydilli G, Goktolga U. Does 75 IU difference improve the cycle performance in poor responders? Comparison of daily 375 versus 450 IU gonadotrophin doses. Gynecol Endocrinol. 2011 Dec;27(12):1001-6.
Korkmaz C, Cinar O, Akyol M. The relationship between meiotic spindle imaging and outcome of intracytoplasmic sperm injection: a retrospective study. Gynecol Endocrinol. 2011 Oct;27(10):737-41.
Aydin S, Cinar O, Demir B, Korkmaz C, Ozdegirmenci O, Dilbaz S, Goktolga U. Is pronuclear scoring a really good predictor for ICSI cycles? Gynecol Endocrinol. 2011 Oct;27(10):742-7.
Guvendag Guven ES, Dilbaz S, Ceylaner S, Acar H, Cinar O, Ozdegirmenci O, Karcaaltincaba D. An uncommon complementary isochromosome of 46,XY,i(9)(p10),i(9)(q10) in an infertile oligoasthenoteratozoospermic man. Fertil Steril. 2011 Jan;95(1):290.e5-8.
Ozdegirmenci O, Dilbaz S, Cinar O, Aydin S, Beydilli G, Cakir L, Guven ES, Akyol M, Haberal A. Can serum oestradiol be a predictor of quality of oocytes and embryos, maturation of oocytes and pregnancy rate in ICSI cycles? Gynecol Endocrinol. 2011 Apr;27(4):279-85.
Kinay T, Tasci Y, Dilbaz S, Cinar O, Demir B, Haberal A. The relationship between endometrial thickness and pregnancy rates in GnRH antagonist down-regulated ICSI cycles. Gynecol Endocrinol. 2010 Nov;26(11):833-7
Cinar O, Seval Y, Uz YH, Cakmak H, Ulukus M, Kayisli UA, Arici A. Differential regulation of Akt phosphorylation in endometriosis. Reproductive BioMedicine Online. 2009 Dec;19(6):864-71.
Cinar O, Can A, Semiz O. Nokodazol hücre döngüsü eş zamanlaması için kullanılabilir mi? (Can nocodazole be used to synchronize cell cycle?) Turkiye Klinikleri J Med Sci. 2008; 28, 437-444.
Kara F, Cinar O, Erdemli-Atabenli E, Tavil-Sabuncuoglu B, Can A. Ultrastructural alterations in human decidua in miscarriages compared to normal pregnancy decidua. Acta Obstet Gynecol Scand. 2007;86(9):1079-86.
Karahuseyinoglu S, Cinar O, Kilic E, Kara F, Akay GG, Demiralp DO, Tukun A, Uckan D, Can A. Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells. 2007 Feb;25(2):319-31.
Cinar O, Semiz O, Can A. A microscopic survey on the efficiency of well-known routine chemical fixatives on cryosections. Acta Histochem. 2006;108(6):487-96.
Ulukus M, Ulukus EC, Seval Y, Cinar O, Zheng W, Arici A. Expression of interleukin-8 receptors in patients with adenomyosis. Fertil Steril. 2006 Mar;85(3):714-20.
Can A, Semiz O, Cinar O. Bisphenol-A induces cell cycle delay and alters centrosome and spindle microtubular organization in oocytes during meiosis. Mol Hum Reprod. 2005 Jun;11(6):389-96.
Can A, Semiz O, Cinar O. Centrosome and microtubule dynamics during early stages of meiosis in mouse oocytes. Mol Hum Reprod. 2003 Dec;9(12):749-56.
Can A, Semiz O, Cinar O. Two convenient methods for nuclear labeling in confocal microscope with visible lasers. Journal of Histotechnology 2003 26:3, 147-156.